DNA Methyltransferase Inhibitors

DNA Methyltransferase

DNMT1

DNMT3

MGMT

DNA Methyltransferase Inhibitors & Degraders

Product Name	DNA Methyltransferase	DNMT1	DNMT3	MGMT	Purity
Decitabine		DNMT1	DNMT3A DNMT3B		99.97%
5-Azacytidine		DNMT1			99.91%
GSK-3484862		DNMT1			99.95%
C188-9		DNMT1			99.84%
MC3817		DNMT1, IC₅₀: 0.044 μM
RG108		CpG methylase M.SssI, IC₅₀: 115 nM			99.93%
SGI-1027		DNMT1, IC₅₀: 12.5 μM	DNMT3B, IC₅₀: 7.5 μM DNMT3A, IC₅₀: 8 μM		99.79%
Zebularine		DNMT1	DNMT3a/3L		99.49%
DY-46-2			DNMT3A, IC₅₀: 0.39 μM		99.86%
Hinokitiol		DNMT1			99.83%
CM-272		DNMT1, IC₅₀: 382 nM	DNMT3A, IC₅₀: 85 nM DNMT3B, IC₅₀: 1200 nM		98.70%
DNMT3A-IN-1			DNMT3A		99.94%
Guadecitabine sodium		DNMT1			99.97%
Nanaomycin A			DNMT3B, IC₅₀: 500 nM		98.18%
Lomeguatrib				MGMT, IC₅₀: 9 nM MGMT, IC₅₀: 6 nM (in MCF-7 cells)	99.77%
γ-Oryzanol		DNMT1, IC₅₀: 3.2 μM	DNMT3A, IC₅₀: 22.3 μM		99.66%
DC-05		DNMT1, Kd: 1.09 μM DNMT1, IC₅₀: 10.3 μM			99.04%
5-Aza-4'-thio-2'-deoxycytidine		DNMT1			99.89%
CM-579 trihydrochloride	DNA Methyltransferase, IC₅₀: 32 nM	DNMT1, Kd: 1.5 nM	DNMT3A, IC₅₀: 92 nM DNMT3B, IC₅₀: 1000 nM
DC_517		DNMT1, Kd: 0.91 μM DNMT1, IC₅₀: 1.7 μM			99.33%
(R)-GSK-3685032		DNMT1			98.97%
Psammaplin A	DNA Methyltransferase, IC₅₀: 18.6 nM
O6BTG-octylglucoside				MGMT, IC₅₀: 32 nM
MS9024		DNMT1, IC₅₀: 430 nM			99.83%
Guadecitabine	DNA Methyltransferase				98.0%
CM-579	DNA Methyltransferase, IC₅₀: 32 nM	DNMT1, Kd: 1.5 nM	DNMT3A, IC₅₀: 92 nM DNMT3B, IC₅₀: 1000 nM
MC3817 free base		DNMT1, IC₅₀: 0.044 μM
DNMT-IN-6		DNMT1	DNMT3A DNMT3B
Isofistularin-3		DNMT1, IC₅₀: 13.5 μM
DNMT1-IN-3		DNMT1, IC₅₀: 0.777 μM
MS1129		DNMT1	DNMT3A DNMT3B
DNMT1-IN-5		DNMT1, IC₅₀: 2.42 μM	DNMT3A, IC₅₀: 14.4 μM
GSK-3484862 (GMP)		DNMT1
DNMT/HDAC-IN-2		DNMT1, IC₅₀: 365 nM
(4aS,8aR)-NPD-001			DNMT3A
MGMT-IN-1				MGMT
RG108 (GMP)		CpG methylase M.SssI, IC₅₀: 115 nM
DNMT-IN-5			DNMT3A, IC₅₀: 9.15 μM
Hedgehog IN-11				MGMT
DNMT-IN-1	DNA Methyltransferase, EC₅₀: 3.2 μM
DNMT1 Degrader-1		DNMT1
Go 6983 (GMP)			DNMT3A
CM-444		DNMT1, IC₅₀: 2.2 μM	DNMT3A, IC₅₀: 1.8 μM DNMT3B, IC₅₀: 2.3 μM

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